isometamidium chloride and diminazene aceturate

One of those was highly susceptible to isometamidium chloride even at the lowest dose rate. In four of the seven isolates high levels of drug resistance to diminazene aceturate and isometamidium chloride were detected. Acta Tropica, 49(1991)201-213 201 Elsevier ACTROP 00149 The effect of diminazene aceturate and isometamidium chloride on cultured procyclic forms of susceptible and drug-resistant Trypanosoma congolense I.E. Two isolates were susceptible to both diminazene aceturate and isometamidium chloride. (1991); the range of drug doses investigated was 10–50 mg/kg b.w. Elrayah and R. Kaminsky International Laboratory for Research on Animal Diseases (ILRAD), Nairobi, Kenva (Received 15 October 1990, accepted 17 January 1991) Cultures of insect … One isolate had a low level of multiple (diminazene aceturate and isometamidium chloride) drug resistance. aceturate: ( ă-set'ū-rāt ), USAN-approved contraction for N- acetylglycinate. In this field guide we will consider only those compounds that are at present available, although they may not be available in each and every country concerned. The susceptibility of seven isolates against isometamidium chloride, diminazene aceturate and homidium chloride was tested in mice using a multiple-dose test. The concentrations of isometamidium circulating in poorly nourished Zebu cattle which showed morbidity, mortality, and biochemical and histopathological evidence of hepatotoxicity, following frequent treatments with isometamidium chloride and diminazene aceturate were investigated using the isometamidium‐ELISA. As few as two isometamidium treatments one month apart were associated … diminazene aceturate, isometamidium chloride and homidium chloride. Investigations were conducted on the sensitivity to isometamidium chloride (Samorin R) and diminazene aceturate (Berenil R) of derivatives of three of the Trypanosoma congolense stocks isolated between 1978 and 1983 from Zebu cattle in the Bobo-Dioulasso region of Burkina Faso. but sometimes isometamidium chloride is used at 0.5-1.0 mg kg-1 where the parasites are sensitive (Gitatha and Ogada 1969; Toure,1970; Williamson, 1970) . For the control of African bovine trypanosomosis the only drugs currently in use are diminazene aceturate, homidium salts and isometamidium chloride, and all have been in use for 35 years or more. for diminazene aceturate, and 1–20 mg/kg b.w. PubMed PMID: 16562737. Boran cattle were used in the drug-sensitivity tests and were infected using Glossina morsitans centralis. isometamidium chloride (0.25 and 0.5 mg/kg), while that of the remaining five relapsed only at the lower dose level. The … The susceptibility of Trypanosoma congolense isolated in Zambézia Province, Mozambique, to isometamidium chloride, diminazene aceturate and homidium chloride. Isometamidium chloride and diminazene aceturate were used by 53.49 and 46.52 % of the responders, respectively. For the control of African bovine trypanosomosis the only drugs currently in use are diminazene aceturate, homidium salts and isometamidium chloride, and all have been in use for 35 years or more. Isometamidium chloride 6 1 Pentamidine 5 5 Diminazene aceturate 2 1 Ethidiumbromide 2 1 T. equiperdum (2 x 107 cells per ml) in RPMI1640 medium/1% BSAweretreated(30min;37°C)withtheindicated drugs(0.001-100,uM) and lysed with SDS. Following drug sensitivity test using the single dose test for diminazene aceturate and isometamidium chloride and a further diminazene-multi-dose tests (Eisler et al., 2001), the Trypanosoma brucei brucei was found to be multidrug-resistant [resistant to both diminazene aceturate (CD 50 = 28.1 mg/kg) and isometamidium chloride]. By contrast, the isometamidium chloride and diminazene aceturate CD50 values for a drug-sensitive clone, T. congolense IL 1180, were 0.018 mg/kg and 2.3 mg/kg, respectively. The in vitro effects of isometamidium chloride (Samorin) on the piscine hemoflagellate Cryptobia salmositica (Kinetoplastida, Bodonina). In dogs, the commonly used drug is diminazene aceturate (usually at 3.5 mg kg-1 body wt.) Two resultant cloned populations (one per isolate) were then characterised in mice for their sensitivities to diminazene aceturate, isometamidium chloride and homidium chloride as described by Peregrine et al. The observed levels of drug resistance could in most cases be correlated to the drug-use practices in the particular livestock production system. For each of the seven isolates, five different doses varying between 0.01-20 mg/kg body weight for isometamidium chloride, 0.01-10 mg/kg body weight for homidium chloride and 1-30 mg/kg body weight for diminazene aceturate were used.


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