clear trial stroke

The prospective, randomized SAMMPRIS trial 6 (Stenting and Aggressive Medical Management for the Prevention of Recurrent Stroke in Intracranial Stenosis) evaluated patients in an extended clinical application of the Wingspan stent, beyond its original HDE clearance labeling in an IDE (Investigational Device Exemption) from the FDA. Eligibility Criteria: Inclusion Criteria: - Patients must have a serious measurable neurological deficit on the NIH Stroke Scale due to focal brain ischemia. The CLEAR Stroke study will enroll 100 participants with acute stroke due to a blood clot. CLEAR III Clinical Trial. Gonzales N (2013) Ongoing Clinical Trials in Intracerebral Hemorrhage, Stroke, 44:6_suppl_1, (S70-S73), Online publication date: 1-Jun-2013. The CLEAR trial was a National Institutes of Health/National Institute of Neurological Disorders and Stroke–funded multicenter, double-blind, randomized, dose-escalation and safety study. BackgroundIn patients with acute ischemic stroke caused by a proximal intracranial arterial occlusion, intraarterial treatment is highly effective for emergency revascularization. CLEAR III is a 500-patient phase 3 randomized clinical trial using a recombinant tissue plasminogen activator (Activase) to quickly … The Interventional Management of Stroke III (IMS-III) trial was an international randomized, multicenter, open label trial of the effect of combined IV/IAT versus IV treatment only, when treatment is initiated within 3 hours in patients with a National Institutes of Health stroke scale (NIHSS) score ≥10. In this randomised, double-blinded, placebo-controlled, multiregional trial (CLEAR III), participants with a routinely placed extraventricular drain, in the intensive care unit with stable, non-traumatic intracerebral haemorrhage volume less than 30 mL, intraventricular haemorrhage obstructing the 3rd or 4th ventricles, and no underlying pathology were adaptively randomly assigned (1:1), via a web-based system to … We aimed to make individual patient data from the International Stroke Trial (IST), one of the largest randomised trials ever conducted in acute stroke, available for public use, to facilitate the planning of future trials and to permit additional secondary analyses. Trial data also reveal that approximately 1 in 5 patients discontinued NOAC therapy. Intraventricular hemorrhage (IVH) is sudden bleeding into the ventricular system of the brain, often the result of severe ICH. 9. These treatments address both the culprit artery (PCI with SYNERGY Stent) as well as the non-culprit arteries (randomization … Results from the study, known as the CLEAR-ER Stroke Trial, are published online in the journal Stroke: Journal of the American Heart Association. Details. CLEAR-ER Stroke Trial Aug 11 2013. 8. - An NIH Stroke Scale score … This website provides information about the recently conducted MR CLEAN trial and substudies. Although effective therapies for stroke prevention exist, there is a clear need for other, better methods of stroke prevention. November 2011 Vol 42, Issue 11

Also, it is the portal for the MR CLEAN Registry. The purpose of this multi-center, randomized, double-blind study is to determine the effects of using a combination of two drugs, integrilin (or eptifibatide) and activase (or recombinant tissue plasminogen activator, rt-PA, recombinant t-PA), to dissolve blood clots. The overall goals of SPOTRIAS are to enhance delivery of acute stroke patient care and train acute stroke translational researchers. Patients were randomized 3:1 to either low-dose rt-PA (tier 1=0.3 mg/kg, tier 2=0.45 mg/kg) plus eptifibatide (75 μ g/kg bolus followed by 0.75 μ g/kg per min infusion for 2 hours) or standard-dose rt-PA (0.9 mg/kg). The Combined Approach to Lysis Utilizing Eptifibatide and rt-PA in Acute Ischemic Stroke-Full Dose Regimen (CLEAR-FDR Stroke Trial) is a Phase II trial and part of the Specialized Program on Translational Research in Acute Stroke (SPOTRIAS). Brief Summary: The CLEAR SYNERGY trial will study the long term effects of treatments following PCI to treat ST elevation myocardial infarction.

Patients were randomized 3:1 to either low-dose rt-PA (tier 1=0.3 mg/kg, tier 2=0.45 mg/kg) plus eptifibatide (75 microg/kg bolus followed by 0.75 microg/kg per min infusion for 2 hours) or standard … The CLEAR-FDR Stroke Trial is designed to provide data concerning the risks when combining eptifibatide with full dose intravenous rt-PA in 30 acute ischemic stroke patients within 3 hours of symptom onset. Compliance is another contributing factor.

This is a registry of all patients with acute ischemic stroke who underwent endovascular treatment in the Netherlands. Methods: The CLEAR trial was a National Institutes of Health/National Institute of Neurological Disorders and Stroke-funded multicenter, double-blind, randomized, dose-escalation and safety study. SURGICAL OR MECHANICAL LAA OCCLUSION . This complication of hemorrhagic stroke has a mortality rate of 60-80%, and only about 10% of patients recover with a good outcome. The combination of tPA with an antiplatelet drug eptifibatide is safe and more effective than tPA alone, a study led by University of Cincinnati (UC) researchers has found..


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