This part of the research deals with materials science, and the results could be used in devel-oping DNA-based nanoelectronics [68] and DNA-templated nanoplasmonics [94]. DNA Origami: Synthesis and Self-Assembly 12.9.2 Supplement 48 Current Protocols in Nucleic Acid Chemistry Figure 12.9.1 The schematic drawing of the structures prepared using the DNA origami method and their AFM images. 1 The DNA origami rectangle with a seam in the middle from Rothemund’s original paper was chosen, as it has been thoroughly studied. We then used SARSE software to aid in the design of face‐shaped DNA origami to demonstrate the selective immobilization of protein on DNA nanostructures.
Recently, dynamic deoxyribonucleic acid (DNA) assemblies have emerged as promising platforms for diagnostics and therapeutics in biomedical applications. The design of staple strand modifications was assisted by use of the SARSE program, DNA-origami efforts to date have not required sequence design, tight control over staple-strand stoichiometry, or purification of staple strands. It consists of eight steps to decide the DNA origami shape and structures, as mentioned below: (see Table 1) 1) tations for positioning DNA origamis on di erent substrates [48, 67, 92], and metallization of various DNA origami shapes [25, 93]. This robustness is a testa- ... well, for example the SARSE program that was used to designacookie-cutterdolphinandasingle-layerbox[10]. The top row represents the folding paths of the scaffold. The various software tools like SARSE and advance tools like caDNAno (computer-aided engineering) display the position of staple strand to build DNA origami design and compute the flexibility, shape and structure of DNA origami [11,12].
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