PURPOSE: To evaluate the safety, pharmacokinetics, and pharmacodynamics of Hu5F9-G4 (5F9), a humanized IgG4 antibody that targets CD47 to enable phagocytosis. Forty Seven was acquired by Gilead Sciences Inc. for $4.9 billion in March. Abstract: S187 Type: Oral Presentation Presentation during EHA25: All oral abstract presentations will be made available on the on-demand Virtual Congress platform as of Friday, June 12 at 08:30 CEST and will be accessible until October 15, 2020. Under the terms of the collaboration, Acerta will sponsor a clinical trial evaluating Forty Seven’s CD47 antibody 5F9 in combination with rituximab plus Acerta’s CALQUENCE ® (acalabrutinib), in patients with diffuse large B-cell lymphoma (DLBCL), an aggressive form of … Forty Seven was acquired by Gilead Sciences Inc. for $4.9 billion in March. The acquisition included magrolimab, a CD47-targeting antibody in clinical trials for several cancers, including myelodysplastic syndrome (MDS), acute myeloid leukemia (AML) and diffuse large B-cell lymphoma (DLBCL). Introduction: Hu5F9‐G4 (5F9) is a first‐in‐class IgG4 antibody targeting CD47, a macrophage immune checkpoint and “don't eat me” signal on cancers leading to phagocytosis of tumor cells. Forty Seven’s lead program, magrolimab, is a monoclonal antibody against the CD47 receptor, a “don’t eat me” signal that cancer cells commandeer to avoid being ingested by macrophages. Acquisition of Forty Seven for $4.9 billion in cash and presence of an additional interested party are proof of interest in this lucrative space.
(5)5 Forty Seven, Menlo Park, CA.
Comment in J Clin Oncol. 2019 Apr 20;37(12):1012-1014. The takeover will give Gilead control of midphase anti-CD47 antibody magrolimab that … Strengths of Forty Seven include a top tier management team, stellar science and lead antibody magrolimab's front runner position in the lucrative CD47 … Forty Seven’s lead program, magrolimab, is a monoclonal antibody against the CD47 receptor, a “don’t eat me” signal that cancer cells commandeer to avoid being ingested by macrophages. Pre‐clinically, 5F9 synergizes with rituximab to eliminate lymphoma by enhancing antibody‐dependent cellular phagocytosis.
They recently announced the extension of an ongoing partnership with Genentech (a Roche company). Go to Gilead has struck a deal to buy Forty Seven for $4.9 billion. Blocking CD47 with Hu5F9-G4 may enable the body's immune system to find and destroy the cancer cells.
Hu5F9-G4 is a monoclonal antibody which is designed to block a protein called CD47, which is widely expressed on human cancer cells. Forty Seven is a clinical-stage immuno-oncology company focused on developing novel checkpoint therapies to activate macrophages in the fight against cancer.
Forty Seven Inc. (NASDAQ: FTSV) is a clinical-stage, publicly traded biotech venture focused on immuno-oncology therapies that activate macrophages to attack on cancer. Forty Seven’s lead drug is magrolimab, a mAb against CD47, the ‘do-not-eat-me’ cue that tumor cells use to evade the immune system’s macrophage-mediated killing.
Forty Seven’s lead program, magrolimab, is a monoclonal antibody against the CD47 receptor, a “don’t eat me” signal that cancer cells commandeer to avoid being ingested by macrophages.
... Forty Seven, Inc. More Information. This antibody is currently being evaluated in multiple clinical studies in patients with myelodysplastic syndrome, acute myeloid leukemia, non-Hodgkin lymphoma, and solid tumors. Gilead Sciences (NASDAQ:GILD) has finalized its $4.9B acquisition of Forty Seven (NASDAQ:FTSV) announced in early March.FTSV's lead candidate is magrolimab, a CD47-targeting monoclonal antibody in Pha
Forty Seven focus its efforts on targeting the CD47 pathway as a way to engage macrophages in fighting tumors. Security issues worthy of attention Forty Seven, Celgene (Inhibrx), Surface Oncology and other companies as pioneers in the development of CD47 target-related antibody drugs, also found and reported a series of safety issues in clinical research, making the safety of CD47 target issues widely … CD47 mAb 5F9 also showed monotherapy activity in a solid phase I trial of Forty Seven. Forty Seven’s lead program, 5F9, is a monoclonal antibody against the CD47 receptor, a “don’t eat me” signal that cancer cells commandeer to avoid being ingested by macrophages. The acquisition included magrolimab, a CD47-targeting antibody in clinical trials for several cancers, including myelodysplastic syndrome (MDS), acute myeloid leukemia (AML) and diffuse large B …
Its core intellectual property asset originates with Irv Weissman and colleagues at Stanford University, focusing on the identification of the CD47-SIRP…
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